African Evaluation Database

9120 records found

Source	Electronic ID	Title	Authors	Publication Year	Source Title	Volume	Issue	DOI	Affiliations	Authors with Affiliations	Abstract	Author Keywords	Index Keywords	Funding Details
Scopus	2-s2.0-84895076158	Evaluation of the antidiarrhoeal activity of the hydroethanolic leaf extract of Pupalia lappacea ...	Akindele A.J., Salako O.A., Ohonbamu U.V.	2014	Journal of Ethnopharmacology	151	2	10.1016/j.jep.2013.12.013	Department of Pharmacology, Therapeutics and Toxicology (PTT), College of Medicine, University of...	Akindele, A.J., Department of Pharmacology, Therapeutics and Toxicology (PTT), College of Medicin...	Ethnopharmacological Relevance Pupalia lappacea is a medicinal plant found in savannah and woodla...	Antidiarrhoeal activity; Castor oil; Intestinal transit; Loperamide; Pupalia lappacea	Antidiarrhoeal activity; Castor oil; Intestinal transit; Loperamide; Pupalia lappacea; Amaranthac...	None	View
Scopus	2-s2.0-84896825415	Pharmacoeconomic evaluation of anti diabetic treatment at ayder referral hospital, Mekelle, Ethiopia	Assefa B., Wondimu A., Abrha S., Dinda S.C., Demeke B., Gebre-Samuel N., Assen A., Molla F., Yilm...	2014	International Journal of Pharmaceutical Sciences Review and Research	25	1	None	Department of Pharmacy, College of Health Sciences, Mekelle University, P.O.Box 1871, Mekelle, Et...	Assefa, B., Department of Pharmacy, College of Health Sciences, Mekelle University, P.O.Box 1871,...	Diabetes mellitus (DM) is a chronic disorder that poses huge health and economic burden on societ...	Complication; Cost of illness; Diabetes mellitus; Direct medical cost; Direct non-medical cost	acetylsalicylic acid; amitriptyline; atenolol; enalapril; furosemide; glibenclamide; hemoglobin A...	None	View
Scopus	2-s2.0-84918513445	Evaluation of neuropharmacological effects of aqueous leaf extract of Albizia glaberrima (Legumin...	Adebesin I.F., Akindele A.J., Adeyemi O.O.	2014	Journal of Ethnopharmacology	160	None	10.1016/j.jep.2014.11.040	Department of Pharmacology, Therapeutics and Toxicology (PTT), University of Lagos, Idi-Araba Cam...	Adebesin, I.F., Department of Pharmacology, Therapeutics and Toxicology (PTT), University of Lago...	Ethnopharmacological relevance Albizia glaberrima is a shrub found in the deciduous forest and ju...	Albizia glaberrima; Anticonvulsant; Anxiolytic; Muscle relaxant; Sedative-hypnotic	Albizia glaberrima extract; diazepam; flavonoid; pentetrazole; phenol derivative; picrotoxin; pla...	None	View
Scopus	2-s2.0-84896065245	Evaluation of haematological, hepatic and renal functions of petroleum tanker drivers in Lagos, N...	Awodele O., Sulayman A.A., Akintonwa A.	2014	African Health Sciences	14	1	None	Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos...	Awodele, O., Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, Univer...	Background: Hydrocarbons which are among the major components of petroleum products are considere...	Hydrocarbons; Liver functions; Oxidative stress; Petroleum tanker drivers; Renal	alanine aminotransferase; albumin; alkaline phosphatase; creatinine; petroleum; urea; adult; alan...	None	View
Scopus	2-s2.0-84962547587	Toxicological evaluation of the aqueous stem bark extract of Bridelia ferruginea (Euphorbiaceae) ...	Awodele O., Amagon K.I., Agbo J., Prasad M.N.V.	2015	Interdisciplinary Toxicology	8	2	10.1515/intox-2015-0014	Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos...	Awodele, O., Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, Univer...	Bridelia ferruginea is a woody shrub that grows in the Savannah or rain forests of Africa and has...	biochemistry; Bridelia ferruginea; hematology; oxidative stress; sperm count	None	None	View
Scopus	2-s2.0-84865172349	Evaluation of some central nervous system properties of methanolic leaf extract of Alstonia boonei	Iniage L.O., Okpo S.O., Olung J.E.	2011	International Journal of Health Research	4	4	None	Department of Pharmacology, Toxicology University of Benin, Benin City, Nigeria	Iniage, L.O., Department of Pharmacology, Toxicology University of Benin, Benin City, Nigeria; Ok...	Purpose: To evaluate some central nervous system activity of methanolic leaf extract of Alstonia ...	Alstonia boonei; Methanolic extract; Motor in-coordination; Rotarod	Alstonia boonei extract; central nervous system agents; phenobarbital; unclassified drug; Alstoni...	None	View
Scopus	2-s2.0-79961242007	Evaluation of analgesic and anti-inflammatory activities and phytochemical screening of the leave...	Ior L.D., Uguru M.O., Olotu P.N., Ohemu T.L., Ukpe A.	2011	Journal of Chemical and Pharmaceutical Research	3	4	None	Department of Pharmacology, University of Jos, Jos, Nigeria; Department of Pharmacognosy, Univers...	Ior, L.D., Department of Pharmacology, University of Jos, Jos, Nigeria; Uguru, M.O., Department o...	The ethanolic extract of the leaves of Paullinia pinnata was evaluated for its analgesic and anti...	Analgesic; Anti-inflammatoryactivity; Paullinia pinnata; Phytochemical screening	acetylsalicylic acid; alkaloid; analgesic agent; antiinflammatory agent; carbohydrate; cardiac gl...	None	View
Scopus	2-s2.0-84924340806	Evaluation of analgesic property of petroleum ether/ethyl acetate stem bark extract and fractions...	Iliya H.A., Woode E.	2015	Journal of Applied Pharmaceutical Science	5	2	10.7324/JAPS.2015.50214	Department of Pharmacology, University of Jos, Jos, Nigeria; Department of Pharmacology, Faculty ...	Iliya, H.A., Department of Pharmacology, University of Jos, Jos, Nigeria, Department of Pharmacol...	This study investigated the possible antinociceptive action of the petroleum ether/ethyl acetate ...	Analgesic property; Fractions; Hyperalgesia; Maerua angolensis	None	None	View
Scopus	2-s2.0-84941642623	Evaluation of predictive CYP2C19 genotyping assays relative to measured phenotype in a South Afri...	Dodgen T.M., Drögemöller B.I., Wright G.E.B., Warnich L., Steffens F.E., Cromarty A.D., Alessandr...	2015	Pharmacogenomics	16	12	10.2217/pgs.15.80	Department of Pharmacology, University of Pretoria, Pretoria, South Africa; Department of Immunol...	Dodgen, T.M., Department of Pharmacology, University of Pretoria, Pretoria, South Africa, Departm...	Aim: To align predicted and measured CYP2C19 phenotype in a South African cohort. Materials & met...	activity score system; CYP2C19; genotype-phenotype correlation; omeprazole; South Africa	5' hydroxyomperazole; cytochrome P450 2C19; drug metabolite; omeprazole; unclassified drug; adult...	None	View
Scopus	2-s2.0-73449131484	Ethnobotanical survey and preliminary evaluation of medicinal plants with antidiarrhoea propertie...	Etuk E.U., Ugwah M.O., Ajagbonna O.P., Onyeyili P.A.	2009	Journal of Medicinal Plants Research	3	10	None	Department of Pharmacology, Usmanu Danfodiyo University, Sokoto, Nigeria; Faculty of Veterinary M...	Etuk, E.U., Department of Pharmacology, Usmanu Danfodiyo University, Sokoto, Nigeria; Ugwah, M.O....	Ethnobotanical survey of medicinal plants use in Sokoto state of Nigeria for the treatment of dia...	Diarrhoea; Medicinal plants; Oral administration; Wistar rats	Acacia nilotica extract; Acacia polyancatha extract; alkaloid; Ampelocissos grantii extract; Anac...	None	View
Scopus	2-s2.0-84895421212	In vitro, in vivo, and in Silico evaluation of the bioresponsive behavior of an intelligent intra...	Du Toit L.C., Carmichael T., Govender T., Kumar P., Choonara Y.E., Pillay V.	2014	Pharmaceutical Research	31	3	10.1007/s11095-013-1184-3	Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersr...	Du Toit, L.C., Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of...	Purpose: An autofeedback complex polymeric platform was used in the design of an intelligent intr...	in vivo test; inflammation; intraocular implant; molecular modeling; physicochemical properties; ...	ciprofloxacin; hydroxyl radical; indometacin; polymer; polysaccharide; animal experiment; animal ...	None	View
Scopus	2-s2.0-84893649409	Evaluation of the impacts of formulation variables and excipients on the Drug release dynamics of...	Adeleke O.A., Choonara Y.E., Kumar P., Du Toit L.C., Tomar L.K., Tyagi C., Pillay V.	2013	AAPS PharmSciTech	14	4	10.1208/s12249-013-0021-7	Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersr...	Adeleke, O.A., Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of...	Drug release from hydrophilic matrices is regulated mainly by polymeric erosion, disentanglement,...	Excipients; Formulation variables; Mathematical tools; Monolithic matrix; Polyamide 6 10	aluminum sulfate; amitriptyline; electrolyte; excipient; magnesium sulfate; polyamide; potassium ...	None	View
Scopus	2-s2.0-67650585880	In vitro transcorneal diffusion of the antimicrobial macrolides azithromycin and clarithromycin a...	Van Eyk A.D., Seifart H.I., Meyer D., Van Der Bijl P.	2009	Cornea	28	4	10.1097/ICO.0b013e31818c901f	Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersr...	Van Eyk, A.D., Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of...	PURPOSE: To compare the in vitro penetration of azithromycin and clarithromycin across both human...	Azithromycin; Clarithromycin; Cornea; In vitro diffusion; Permeability	azithromycin; carbomer; clarithromycin; phosphate buffered saline; polyacrylic acid; antimicrobia...	None	View
Scopus	2-s2.0-84930182018	In vitro, ex vivo and in silico mechanistic elucidation of the performance of an optimized porosi...	Adeleke O.A., Choonara Y.E., Du Toit L.C., Kumar P., Pillay V.	2015	Pharmaceutical Research	32	7	10.1007/s11095-015-1631-4	Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersr...	Adeleke, O.A., Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of...	Purpose: To elucidate the mechanisms of construction and performance of a porosity controlled, mu...	Computational modeling; Experimental analyses; Mechanisms of construction and performance; Porosi...	alcohol; phenytoin; polymer; water; animal tissue; Article; cheek mucosa; computer model; differe...	None	View
Scopus	2-s2.0-45349090253	The evaluation of low-density lipoprotein cholesterol goals achieved in patients with established...	Ramjeeth A., Butkow N., Raal F., Maholwana-Mokgatlhe M.	2008	Cardiovascular Journal of Africa	19	2	None	Department of Pharmacy and Pharmacology, School of Therapeutic Science, University of the Witwate...	Ramjeeth, A., Department of Pharmacy and Pharmacology, School of Therapeutic Science, University ...	Aim: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Dysl...	None	antilipemic agent; atorvastatin; fluindostatin; hydroxymethylglutaryl coenzyme A reductase inhibi...	None	View
Scopus	2-s2.0-79955707100	Evaluation of horizontal surface solar radiation levels in southern Nigeria	Dike V.N., Chineke T.C., Nwofor O.K., Okoro U.K.	2011	Journal of Renewable and Sustainable Energy	3	2	10.1063/1.3558871	Department of Physics, Atmospheric Physics Group, Imo State University, P.M.B., 2000 Owerri, Nigeria	Dike, V.N., Department of Physics, Atmospheric Physics Group, Imo State University, P.M.B., 2000 ...	Solar energy, which is inexhaustible and abundant, has become an economically viable and environm...	None	Energy security; Global solar radiation; Hargreaves; Horizontal surfaces; National aeronautics an...	None	View
Scopus	2-s2.0-84928322739	In silico mechanistic disposition and in vivo evaluation of zero-order drug release from a novel ...	Moodley K., Choonara Y.E., Kumar P., Du Toit L.C., Pillay V.	2015	Expert Opinion on Drug Delivery	12	5	10.1517/17425247.2015.989208	Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of the Witwat...	Moodley, K., Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University ...	Objectives: The purpose of this study was to formulate novel triple-layered tablet (TLT) matrices...	Cardiovascular therapeutic regimen; in vivo drug release behavior; Large White Pig Model; Modifie...	acetylsalicylic acid; atenolol; diphenhydramine; drug carrier; macrogol; polyamide; polyglactin; ...	None	View
Scopus	2-s2.0-79951889468	In vivo evaluation of the release of zidovudine and polystyrene sulfonate from a dual intravagina...	Ndesendo V.M.K., Pillay V., Choonara Y.E., Du Toit L.C., Meyer L.C.R., Buchmann E., Kumar P., Kha...	2011	Journal of Pharmaceutical Sciences	100	4	10.1002/jps.22365	Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown 2...	Ndesendo, V.M.K., Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 Yor...	This study focused on determining the concentration of zidovudine (AZT) and polystyrene sulfonate...	Formulation; HIV/AIDS; Intravaginal drug delivery; Molecular dynamics; Permeability; large white ...	mucin; polymer; polystyrenesulfonic acid; subtilisin; zidovudine; anti human immunodeficiency vir...	None	View
Scopus	2-s2.0-67049096368	Mechanistic evaluation of alginate-HEC gelisphere compacts for controlled intrastriatal nicotine ...	Choonara Y.E., Pillay V., Khan R.A., Singh N., Du Toit L.C.	2009	Journal of Pharmaceutical Sciences	98	6	10.1002/jps.21590	Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, Parktown 2...	Choonara, Y.E., Department of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York ...	This study focused on elucidating a mechanistic understanding in support of the multiple mechanis...	Bioavailability; Biomaterials; Blood-brain barrier; Controlled release; Crosslinking; Gelispheres...	alginic acid; barium; calcium; hydroxyethylcellulose; monomer; nicotine; polyglactin; transferase...	None	View
Scopus	2-s2.0-84881028983	Design of an anti-inflammatory composite nanosystem and evaluation of its potential for ocular dr...	Du Toit L.C., Govender T., Carmichael T., Kumar P., Choonara Y.E., Pillay V.	2013	Journal of Pharmaceutical Sciences	102	8	10.1002/jps.23650	Department of Pharmacy and Pharmacology, University of the Witwatersrand, Parktown, Johannesburg ...	Du Toit, L.C., Department of Pharmacy and Pharmacology, University of the Witwatersrand, Parktown...	This study compared two specific embodiments of an ocular nanosystem (NS): one portraying a purel...	Cell uptake; Computational modeling; Confocal microscopy; ELISA; Lipids; Liposomes; permeation; N...	4 chloro 7 nitrobenzofurazan; chitosan; ganciclovir; I kappa B; indometacin; liposome; nanopartic...	None	View

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