Karunasree V., Veeresham C., Sambasiva Rao K.R.S., Asres K.
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India; University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP 506009, India; Department of Biotechnology, Acharya Nagarjuna University, Guntur, AP, 522510, India; Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
Karunasree, V., KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, AP, 520010, India; Veeresham, C., University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP 506009, India; Sambasiva Rao, K.R.S., Department of Biotechnology, Acharya Nagarjuna University, Guntur, AP, 522510, India; Asres, K., Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia
Diabetes has become a worldwide problem afflicting humans irrespective of age. Even though a number of synthetic drugs are available for the treatment of diabetes, plant drugs are generally preferred due to the assumption that they have less side effects and low cost. This study reports the hypoglycaemic and antihyperglycaemic actions of the methanolic bark extract of Soymida febrifuga A. Juss. (fam: Meliaceae) in euglycaemic and alloxan-induced diabetic rats, respectively. The results revealed that three column fractions obtained from the methanol extract of S. febrifuga possess maximum hypoglycaemic and antihyperglycaemic activities 6 h after treatment. At a dose of 200 mg/kg, the relatively nonpolar column fraction obtained by using 20% chloroform in acetone as an eluent was by far the most potent fraction which showed comparable activity with that of the standard drug glibenclamide (10 mg/kg). At a dose of 200 mg/kg, the same column eluate showed maximum antihyperglycaemic effect reducing blood glucose level by 33.00%. At a dose of 10 mg/kg, the reference drug glibenclamide brought about 33.46% reduction of blood glucose level. In light of the results obtained from the current study, it could be concluded that the bark of S. febrifuga has genuine antidiabetic activity. © 2012 Pharmacognosy Network Worldwide [Phcog.Net].
antidiabetic agent; chloroform; cholesterol; glibenclamide; glucose; insulin; plant extract; protein; Soymida febrifuga extract; triacylglycerol; unclassified drug; alloxan diabetes mellitus; animal experiment; animal model; antidiabetic activity; article; bark; body weight; cholesterol blood level; controlled study; diabetes control; drug dose comparison; drug efficacy; drug isolation; drug potency; drug response; drug screening; glucose blood level; glycemic control; insulin blood level; medicinal plant; Meliaceae; nonhuman; phytochemistry; protein blood level; rat; Soymida febrifuga; triacylglycerol blood level
