Mbulawa Z.Z.A., Johnson L.F., Marais D.J., Coetzee D., Williamson A.-L.
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa; Center for HIV and STIs, National Institute for Communicable Disease, National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa
Mbulawa, Z.Z.A., Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa, Center for HIV and STIs, National Institute for Communicable Disease, National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa; Johnson, L.F., Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa; Marais, D.J., Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa; Coetzee, D., Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, South Africa; Williamson, A.-L., Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa, National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa
Objectives: This study investigated HPV transmission and the factors influencing it in heterosexually active couples in South Africa. Methods: A total of 486 heterosexual couples were recruited at a health facility and returned at 6-monthly intervals. Cervical and penile HPV types were determined by Roche Linear Array HPV genotyping assay. HPV transmission was defined as the detection of a new HPV type in an individual whose partner was infected with the same type at the date of acquisition. Results: The female-to-male HPV transmission rate was 2.80/100 person-months (95% confidence interval (CI): 2.03-3.86) while the male-to-female HPV transmission rate was 1.17/100 person-months (95% CI: 0.82-1.67). HIV-positive women were found to be at higher risk of HPV infection transmitted from their male partners compared to HIV-negative women (RR (relative risk): 2.31, 95% CI: 1.08-4.92, P=0.03). HIV-positive men with CD4 counts <350/mL had a higher risk of HPV infection transmitted from their female partners compared to HIV-positive men with CD4 counts ≥350/mL (RR: 3.17, 95% CI: 1.05-9.55, P=0.04). Conclusions: HIV infection and low CD4 counts increase the rate of HPV acquisition from sexual partner. © 2013 The British Infection Association.
adult; age distribution; aged; article; CD4 lymphocyte count; controlled study; disease severity; female; genotype; health care facility; heterosexuality; human; Human immunodeficiency virus; Human immunodeficiency virus infection; major clinical study; male; papillomavirus infection; risk assessment; risk factor; sexual behavior; virus transmission; Wart virus; Adolescent; Adult; Aged; CD4 Lymphocyte Count; Cervix Uteri; Family Characteristics; Female; Genotype; Heterosexuality; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Papillomaviridae; Papillomavirus Infections; Penis; Risk Factors; South Africa; Young Adult
