Mbulawa Z.Z.A., Marais D.J., Johnson L.F., Coetzee D., Williamson A.-L.
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Rd, 7925 Cape Town, South Africa; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa
Mbulawa, Z.Z.A., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Rd, 7925 Cape Town, South Africa; Marais, D.J., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Rd, 7925 Cape Town, South Africa; Johnson, L.F., Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; Coetzee, D., Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; Williamson, A.-L., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Rd, 7925 Cape Town, South Africa, National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa
Background. This study investigated genital human papillomavirus (HPV) incidence and clearance in 278 human immunodeficiency virus (HIV)-seropositive (HIV-positive) women, 208 HIV-negative women, 161 HIV-positive men, and 325 HIV-negative men, followed at 6-month intervals for up to 24 months. Methods. HPV types were determined by the Roche Reverse Linear Array HPV genotyping assay. Results. The rate of new HPV detection at the cervix and penis were 33.83 events/1000 person-months (95 confidence interval [CI], 26.39-43.46) and 55.68 events/1000 person-months (95 CI, 43.59-69.19), respectively. HIV infection was associated with increased risk of new HPV detection in women (relative risk [RR], 2.98; 95 CI, 2.07-4.29) and men (RR, 2.00; 95 CI, 1.49-2.69). The risk of new HPV detection increased in women (RR, 5.25; 95 CI, 3.52-7.81) and men (RR, 8.71; 95 CI, 6.19-12.24) when the sexual partner was infected with the same HPV type. The rate of clearing any HPV infection was 95.1 events/1000 person-months (95 CI, 83.3-108.1) in men and 66.9 events/1000 person-months (95 CI, 57.0-78.5) in women. HIV infection reduced the rate of HPV clearance in women (RR, 0.46; 95 CI,. 34-.62) and men (RR, 0.71; 95 CI,. 55-.93). Conclusions. HIV infection increases the risk of new HPV detection and decreases the rate of HPV clearance in both women and men. © 2012 The Author.
adult; aged; article; CD4 lymphocyte count; contraception; controlled study; disease association; female; follow up; genital system disease; genital tract infection; genital ulcer; genotyping technique; groups by age; health status; history; human; Human immunodeficiency virus; human relation; infection rate; infection risk; major clinical study; male; mixed infection; papillomavirus infection; parity; penis; priority journal; sexual behavior; sexuality; uterine cervix; viral clearance; virus detection; virus load; Adolescent; Adult; Aged; Cervix Uteri; Female; Follow-Up Studies; Genotype; HIV; HIV Infections; HIV Seropositivity; Humans; Incidence; Male; Middle Aged; Natural History; Papillomaviridae; Papillomavirus Infections; Penis; Sexual Partners; South Africa; Young Adult
