Shailaja T., Latha K., Alkabab A.M., Sasibhushan P., Uhumwangho M.U.
G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria
Shailaja, T., G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Latha, K., G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Alkabab, A.M., G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Sasibhushan, P., G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Uhumwangho, M.U., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria
The main objective of the study is to formulate and evaluate orodispersible tablets of metoprolol tartrate with natural and synthetic superdisintegrants. Various formulations of metoprolol tartrate were prepared by direct compression method using different ratios of natural superdisintegrant (agar, treated agar) and synthetic superdisintegrants (sodium starch glycolate, croscarmellose sodium and crospovidone) at the concentrations ranging from 3%-12%. The drug and excipients compatibility study was performed by FTIR to study the interaction between drug and excipients. The blend of all formulations were evaluated for various precompressional parameters such as angle of repose, bulk, tapped densities, compressibility index, Hausner's ratio and the prepared tablets were evaluated for various parameters like weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, content uniformity and in vitro drug release. Formulations with treated agar have shown promising results compared to other formulations with semisynthetic superdisintegrants. The optimized formulation was subjected to stability studies for three months as per ICH guidelines. Disintegration times of formulations containing treated agar were found to be in the range 30-19sec and 95-100% drug release was observed in 5 min. The optimized formulation was found to be stable with insignificant change in the hardness, disintegration time, drug content and in vitro drug release.
agar; croscarmellose sodium; crospovidone; disintegrating agent; metoprolol tartrate; starch glycolate sodium; angle of repose; article; bulk density; content uniformity; dispersible tablet; drug release; drug solubility; drug stability; excipient compatibility; Hausner ratio; infrared spectroscopy; tablet compression; tablet disintegration time; tablet formulation; tablet friability; tablet hardness; tablet property; tablet thickness; water absorption; weight
