Latha K., Uhumwangho M.U., Sunil S.A., Srikanth M.V., Ramana Murthy K.V.
G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria; University College of Pharmaceutical Sciences, Andhra University, Vi
Latha, K., G. Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad, 500 028, India; Uhumwangho, M.U., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria; Sunil, S.A., University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India; Srikanth, M.V., University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India; Ramana Murthy, K.V., University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
The purpose of this study is to investigate the release profile of a formulated oral timed- release tablet of losartan potassium using guar gum. Timed- release tablets (TRT) containing losartan potassium in the core tablets were prepared by dry coating technique using different ratios of guar gum, PEG 6000,SSG mixture as the outer coating polymer. The following parameters are investigated: Tensile strength, friability, in vitro dissolution studies and drug content. The formulation was further characterized with powder X-ray diffraction (PXRD) and Fourier-Transform Infrared to investigate drug/or excipient modification and/or interaction. The results showed that the tensile strength values of all the TRT were between 1.06- 1.08 MN/m2 while their friability values were <0.34%. The TRT showed a lag time before burst release of losartan potassium. The lag time(less than 10% drug release) of TRT1, TRT2, TRT3, TRT4 and TRT5 were not definite. Of all the TRT formulations TRT6 showed a clear lag time of 6h before burst release of the drug (63.4%). Drug content of all the TRT was >99.5%. There was no physical and chemical interaction or complexation throughout the process of formulation and compression. Optimized chronotherapeutic drug delivery systems of losartan potassium (TRT6) using guar gum: PEG 6000: SSG with weight ratio 50:40:10 has been developedgave the required lag time of 5-7 hrs prior to the drug release. The dosage form administered before going to the bed and release was observed after 5-7 hrs of lag time that is in early hours of the morning where it needs to conteract the increased blood pressure due to the stimulation of angiotensin-aldosterone system. There was no modification and/ or interaction or complexation of the drug and added excipients throughout the process of formulation and compression.
excipient; gum arabic; losartan; macrogol 6000; article; blood pressure; chronotherapy; compression; drug delivery system; drug formulation; drug release; Fourier transformation; in vitro study; physical chemistry; renin angiotensin aldosterone system; solid; tablet friability; tensile strength; X ray diffraction
