Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Department of Biochemistry, College of Health Sciences, University of Uyo, Uyo, Nigeria; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Phar
Okokon, J.E., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria; Ekpo, A.J., Department of Biochemistry, College of Health Sciences, University of Uyo, Uyo, Nigeria; Eseyin, O.A., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
The leaves and seeds of Telfairia occidentalis are used as vegetables in making soups in Southern Nigeria. In this study, we investigated the antimalarial activity of leaf and seed extracts in vivo in mice infected with Plasmodium berghei berghei during early and established infections. T. occidentalis leaf extract (250-750mg/kg/day) exhibited antiplasmodial activity both in the 4-day early infection test and in established infection with a marked increase of the mean survival time, which, however, remained lower than that achieved with the standard drug, chloroquine (5mg/kg/day). The seed extract (450-1,350mg/kg/day) also demonstrated a promising blood schizontocidal activity in early and established infections. This plant possesses significant antiplasmodial activities, which may be exploited in the control of malaria. © Copyright 2009, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition.
chloroquine; plant extract; Telfairia occidentalis extract; unclassified drug; animal experiment; animal model; antimalarial activity; article; controlled study; female; malaria; malaria control; male; medicinal plant; mouse; nonhuman; plant leaf; plant seed; Plasmodium berghei; priority journal; Telfairia occidentalis; Animals; Antimalarials; Chloroquine; Cucurbitaceae; Female; Malaria; Male; Mice; Nigeria; Phytotherapy; Plant Extracts; Plant Leaves; Plasmodium berghei; Seeds; Mus; Plasmodium berghei; Telfairia occidentalis
