Esimone C.O., Onuh P.U., Obitte N.C., Egege M.K., Ugoeze K.C.
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Departmen
Esimone, C.O., Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Onuh, P.U., Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Obitte, N.C., Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Egege, M.K., Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Portharcourt, Nigeria; Ugoeze, K.C., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
The aim of this research was to formulate Zapoteca portoricensis root extract as Lozenges and to evaluate some of their antimicrobial and tablet properties. The root extracts were formulated into Lozenges using either Sodium Carboxy Methyl Cellulose (SCMC) or Carboxy Methyl Cellulose (CMC) as binders. Uniformity of weight, crushing strength, microbial sensitivity and pre-extinction time studies (using E. coli, S. aureus and Candida albicans) were conducted on three Lozenges formulated with either SCMC (Batch A), CMC (Batch B) and a reference standard, DequadinR, containing dequalinium hydrochloride (Batch C). Results showed that Batches B and C passed the weight uniformity test. The three batches had mean crushing strengths of 4.86±0.043, 3.9±0.03 and 13.1±0.43 KgF, respectively for A, B and C. S. aureus and Candida alhicans were sensitive to the test lozenges whereas Escherichia coli was not. Candida albicans was minimally sensitive to the standard lozenge, while S. aureus was not. Both the test and the standard samples showed extinction times greater than 30 min. © 2009 Academic Journals Inc.
antibiotic agent; carboxymethylcellulose; dequalinium; plant extract; unclassified drug; Zapoteca portoricensis extract; antibiotic sensitivity; antimicrobial activity; article; Candida albicans; controlled study; crushing strength; drug screening; Escherichia coli; in vitro study; legume; lozenge; nonhuman; plant root; Staphylococcus aureus; tablet formulation; timed drug release; weight; Zapoteca portoricensis
