Attama A.A., Uzor P.F., Nnadi C.O., Okafor C.G.
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nig
Attama, A.A., Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Uzor, P.F., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Nnadi, C.O., Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Okafor, C.G., Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
The methanol leaf extract of Aspila africana formulated as gels was studied for its potency on experimentally-induced wound in rats. Wounds were inflicted on Wistar rats using excision model. The extract was formulated as hydrogel and xerogel. The wound healing effects of the formulations were compared to that of a standard antibiotic, Cicatrin® together with the gel bases. In all cases, there was a progressive decrease in wound area with time. A 100% wound closure was observed by the 17 th day post wound day in both gel formulations of the extract and the standard. It was concluded that the extract formulated in gel forms were effective in healing wounds.
antibiotic agent; Aspila africana extract; cicatrin; methanol; plant extract; unclassified drug; article; Aspila africana; controlled study; drug activity; drug effect; drug formulation; drug potency; drug screening; excision; familia; gel; hydrogel; nonhuman; plant; plant leaf; rat; Wistar rat; wound closure; wound healing; xerogel
