Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; University Teaching Hospitals, Port Harcourt, Nigeria
Jackson, C., Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; Agboke, A., Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria; Nwoke, V., University Teaching Hospitals, Port Harcourt, Nigeria
The in vitro combined effects of Nystatin and methanol extract of leaves of Euphorbia hirta against clinical isolates of Candida albicans were investigated using the Checkerboard technique. The organism was susceptible to the extract with MIC of 25 mg/ml, while Nystatin had MIC of 0.165 mg/ml against C. albicans. Upon combination, some ratios showed synergistic while others indicated indifferent activities against the isolates. These results indicate that some combinations of the extract with nystatin could be synergistic in activity for some ratio combinations and indifferent for some others. © 2009 Academic Journals.
Euphorbia hirta extract; methanol; nystatin; plant extract; unclassified drug; antibiotic sensitivity; antimicrobial activity; article; Candida albicans; checkerboard method; drug potentiation; drug screening; Euphorbia; euphorbia hirta; fungus isolation; in vitro study; minimum inhibitory concentration; nonhuman; Candida albicans; Chamaesyce hirta
