Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Eichie, F.E., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Isesele, J.E., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Abhulimen, M.-A.O., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Purpose: To investigate the sustained release characteristics of ibuprofen lipospheres made from Capra hircus (GF) and carnauba wax (CW) in comparison with conventional granules as standard. Methods: Ibuprofen (90 g) and the lipid (30 g) were prepared by melt dispersion technique. Conventional granules of ibuprofen were prepared with starch mucilage, 20% w/v. Resulting lipospheres were characterized with respect to sizes, flow property, bulk and tap densities, encapsulated in hard gelatin capsules and evaluated for drug release profiles. Results: Dissolution profile for lipospheres were a maximum drug release of 97% in 1 hr (conventional granules), 23% in 4 hr (GF), 60% in 2 hr (CW) and 40% in admixtures of fats (GC). Admixing the fats enhanced flow properties of the lipospheres. Inclusion of a surfactant enhanced the release profiles from the lipospheres. Conclusion: Formulation of ibuprofen into lipospheres modified the release profile, which has implications in the formulation of sustained release multiunit dosage forms. © Poracom Academic Publishers. All rights reserved.
Capra hircus fat; carnuba wax; drug carrier; fat; gelatin; ibuprofen; lipid; liposphere; surfactant; unclassified drug; wax; article; bulk density; controlled study; dispersion; drug dosage form comparison; drug granule; encapsulation; flow property; goat; mucilage; particle size; physical parameters; sustained drug release; sustained release formulation
