Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
Gbenga, B.L., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria; Olabanji, O., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria
A study was made of the characterization and formulation of stem bark of Enantia chlorantha into tablet dosage form. Compacts of powdered stem bark of Enantia chlorantha was made with gelatin and polyvinylpyrollidone (PVP) binders; and microcrystalline cellulose and cornstarch disintegrants using direct compression method. The mechanical properties of the tablets were assessed using crushing strength and friability and the crushing strength - friability ratio (CSFR) while drug release properties were evaluated using disintegration and dissolution times. Enantia chlorantha powder possesses good flow properties. It had the least densification compared to cornstarch and cellulose; and it is more porous. It also possesses a relatively high bulk density Tablets formulated with PVP had better mechanical strength than those containing gelatin and the mechanical properties of the tablets were affected by the type and concentration of the binder used. Tablets containing gelatin had lower disintegration times than those formulated with cornstarch. Tablets containing 7. 5% w/w PVP binder and cornstarch had the best release profile with T50 at 60 seconds and T90 at 19 minutes. Results suggest that Enantia chlorantha bark could be formulated into tablet with good mechanical properties and acceptable release profile.
gelatin; herbaceous agent; microcrystalline cellulose; povidone; starch; angle of repose; Annonaceae; article; bark; bulk density; crushing strength; crushing strength and friability ratio; drug release; drug screening; drug solubility; Enatia chlorantha; mechanical strength; moisture; nonhuman; physical chemistry; powder; tablet compression; tablet disintegration time; tablet formulation; tablet friability; tablet property; weight uniformity
