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4074

Source

Scopus

Electronic ID

2-s2.0-84863437399

Authors

Apeji Y.E., Oyi A.R., Musa H.

Title

Formulation and evaluation of ascorbic acid tablets by direct compression using microcrystalline starch as a direct compression excipient

Publication Year

2011

Source Title

International Journal of Health Research

Volume

Issue

Citations

DOI

None

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863437399&partnerID=40&md5=cca491a0f3765dbdc4128316b9c82a8e

Affiliations

Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria

Authors with Affiliations

Apeji, Y.E., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria; Oyi, A.R., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria; Musa, H., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria

Abstract

PURPOSE: To evaluate the tableting properties of microcrystalline starch (MCS) used as a direct compression excipient in the formulation of ascorbic acid tablets and to compare with the properties of tablets produced using microcrystalline cellulose (MCC). METHODS: MCS was obtained by partial hydrolysis of cassava (Manihot esculenta Crantz) starch using the enzyme, α-amylase. The hydrolysis was allowed to proceed for 5 hr under controlled temperature and pH (56 °C, 6). The derived MCS was recovered by filtration after precipitation with ethanol (95%v/v). Powder properties were investigated and tablets of ascorbic acid were formulated using MCS and MCC as direct compression excipients. RESULTS: Mechanical properties of tablets formulated with MCS were comparable to those of MCC. Tablets formulated with MCS disintegrated within 15 min and gave a 100% release of ascorbic acid within 30 min compared to MCC which disintegrated after 60 min. CONCLUSION: MCS can be incorporated as a direct compression excipient in the formulation of heat and/or moisture sensitive drugs by direct compression. © Poracom Academic Publishers. All rights reserved.

Author Keywords

α-amylase; Mechanical properties; Microcrystalline cellulose; Partial hydrolysis; Powder properties

Index Keywords

ascorbic acid; excipient; microcrystalline cellulose; microcrystalline starch; unclassified drug; article; controlled study; crushing strength; drug release; hydrolysis; tablet compression; tablet disintegration time; tablet formulation; tablet friability; tablet porosity; tablet thickness; tensile strength; water absorption

Funding Details

None