Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
Apeji, Y.E., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; Oyi, A.R., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; Musa, H., Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
The aim of this study was to investigate and determine the powder and compaction properties of microcrystalline starch (MCS) and compare with the properties of a well known direct compression filler-binder, microcrystalline cellulose (MCC). Cassava starch was extracted from the freshly harvested tubers of Manihot esculenta Crantz and subjected to 5hours of enzymatic hydrolysis to yield microcrystalline starch. The powder and compaction properties were evaluated and compared with MCC 101, a commercial brand of microcrystalline cellulose. Results of the powder properties of MCS revealed differences in the particle size, angle of repose, flow rate, bulk density, tapped density, true density, Hausner's ratio, Carr's index and powder porosity when compared to MCC. The compaction studies of both materials revealed that MCS had a faster onset of deformation and a greater extent of deformation in comparison to MCC. These results suggest that MCS has the potential of being used as a filler-binder in direct compression tableting.
amylase; microcrystalline cellulose; microcrystalline starch; starch; unclassified drug; article; cassava; controlled study; density gradient; excipient compatibility; flow rate; hydration; hydrolysis; moisture; nonhuman; particle size; tablet compression; tablet formulation; tablet porosity; tablet property
