Chime S.A., Ugwuoke E.C., Onyishi I.V., Brown S.A., Onunkwo G.C.
Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410 001, Nigeria; Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka 410 001, Nigeria; Department of Pharmaceutics and Pharma
Chime, S.A., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410 001, Nigeria; Ugwuoke, E.C., Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka 410 001, Nigeria; Onyishi, I.V., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410 001, Nigeria; Brown, S.A., Department of Pharmaceutics and Pharmaceutical Microbiology, University of Port Harcourt, Port Harcourt, 500 001, Nigeria; Onunkwo, G.C., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410 001, Nigeria
The aim of this work was to formulate Alstonia boonei dried stem bark powder into tablets by wet granulation method using acacia, gelatine and sodium carboxymethyl cellulose as binders at concentrations of 1, 2, 4 and 8% w/w. The phytochemistry of the stem bark of Alstonia boonei was evaluated. The micromeritic properties of the granules prepared were studied. The tablets were evaluated using the necessary official and unofficial tests. The results of the phytochemical analysis showed that alkaloids, tannins, steroids, saponins, glycosides, flavonoids and terpenoids were present while anthroquinones and acidcompounds were absent. Micromeritic studies showed that Alstonia boonei granules had good flowability. The formulated tablets complied with British Pharmacopoeial specification for weight uniformity, hardness (≥5 kgf) and tablet friability (<1%). For disintegration test, tablets formulated with gelatine and acacia at concentrations of 1, 2 and 4% w/w complied with Pharmacopoeial specification. However, tablets formulated with SCMC (1-8% w/w) and 8% w/w of acacia and gelatine failed the disintegration tests (Disintegration time more than 15 min).
alkaloid; Alstonia boonei extract; carboxymethylcellulose; flavonoid; gelatin; glycoside; lactose; magnesium stearate; plant extract; saponin; steroid; tannin derivative; terpenoid; unclassified drug; Alstonia; alstonia boonei; article; bark; concentration (parameters); crushing strength; drug formulation; drug granulation; evaluation; maize; phytochemistry; plant stem; powder; powder flow; tablet; tablet disintegration; tablet friability; tablet hardness
