African Evaluation Database

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4043

Source

Scopus

Electronic ID

2-s2.0-84872385148

Authors

Chime S.A., Attama A.A., Onunkwo G.C.

Title

Sustained release indomethacin-loaded solid lipid microparticles based on solidified reverse micellar solution (SRMS): In vitro and in vivo evaluation

Publication Year

2012

Source Title

Journal of Drug Delivery Science and Technology

Volume

Issue

Citations

DOI

None

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872385148&partnerID=40&md5=67c9c4753849aa13007f4ccfd33dfaff

Affiliations

Department of Pharmaceutical Technology and Industrial Pharmacy, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria

Authors with Affiliations

Chime, S.A., Department of Pharmaceutical Technology and Industrial Pharmacy, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria; Attama, A.A., Department of Pharmaceutical Technology and Industrial Pharmacy, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria; Onunkwo, G.C., Department of Pharmaceutical Technology and Industrial Pharmacy, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria

Abstract

Solidified reverse micellar solutions (SRMS) were formulated using phospholipid (Phospholipon 90H) and triglyceride (Softisan 154) in the ratios of 1:1, 2:1 and 1:2, respectively. SLMs were prepared by melt homogenization technique. Characterization based on yield, mean particle diameter and morphology, pH, thermal analysis and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release was carried out in simulated intestinal fluid (SIF, pH 75), while the anti-inflammatory and ulcerogenic properties were studied using rats. From the results, the mean particle diameter of SLMs ranged from 2.19 ± 0.05 μm to 20.77 ± 0.03 μm. Maximum EE% of 96, 93 and 94% were obtained and showed significant variation within the batches (p < 0.05). The release profile of indomethacin-loaded SLMs showed about 82-99% drug release at 13 h. Indomethacin-loaded SLMs showed good anti-inflammatory and gastro-protective effects, and could be formulated for once-daily administration, either orally or parenterally, under controlled conditions.

Author Keywords

Indomethacin; NSAlDs; Solid lipid microparticles (SLMs); Solidified reverse micellar solutions (SRMS); Sustained release; Ulcerogenicity

Index Keywords

indometacin; phospholipid; phospholipon 90h; softisan 154; solid lipid nanoparticle; triacylglycerol; unclassified drug; antiinflammatory activity; antiulcer activity; article; drug delivery system; drug formulation; drug screening; drug stability; in vitro study; in vivo study; intestine fluid; nanoencapsulation; nonhuman; particle size; paw edema; pH; physical chemistry; rat; solidified reverse micellar solution; stomach protection; sustained drug release; thermal analysis

Funding Details

None